Nat8l Gene Summary [Rat]
Enables L-aspartate N-acetyltransferase activity. Predicted to be involved in acetate metabolic process; aspartate metabolic process; and positive regulation of dopamine uptake involved in synaptic transmission. Located in mitochondrion. Orthologous to human NAT8L (N-acetyltransferase 8 like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nat8l |
| Official Name | N-acetyltransferase 8-like [Source:RGD Symbol;Acc:1305719] |
| Ensembl ID | ENSRNOG00000049351 |
| Bio databases IDs | |
| Aliases | N-acetyltransferase 8-like |
| Synonyms | 1110038O08Rik, CML3, FLJ37478, LOC339984, NACED, N-acetyltransferase 8-like, NAT8-LIKE, RGD1305719, Shati |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nat8l often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- aspartate N-acetyltransferase
- Acetyltransferase (GNAT) family
- NAT_SF
- Acetyltransferase (GNAT) domain
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- N-acetylaspartate deficiency
- osteoarthritis
- spongy degeneration of central nervous system
- demyelination
role in cell
- expression in
- phosphorylation in
- proliferation
- number
- synthesis in
- upregulation in
- respiratory capacity
- degeneration
- browning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- Mitochondria
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nat8l gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- aspartate family amino acid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
- mitochondrial matrix
- cytoplasm
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding
- aspartate N-acetyltransferase activity