Klk11 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in extracellular region. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK11 (kallikrein related peptidase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klk11 |
| Official Name | kallikrein related-peptidase 11 [Source:RGD Symbol;Acc:1308690] |
| Ensembl ID | ENSRNOG00000018742 |
| Bio databases IDs | |
| Aliases | kallikrein related-peptidase 11 |
| Synonyms | 2310015I08RIK, Hippostasin, IEKD, KALLIKREIN 11, kallikrein related-peptidase 11, Klng, PRSS20, TLSP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klk11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine-type peptidase
- peptidase
Pathways
Biological processes and signaling networks where the Klk11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
- ichthyosis with erythrokeratoderma
- psoriasis
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- idiopathic dilated cardiomyopathy
role in cell
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klk11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- secretory granule
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity
- serine-type peptidase activity