Klk14 Gene Summary [Rat]
Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including epidermis morphogenesis; regulation of G protein-coupled receptor signaling pathway; and seminal clot liquefaction. Predicted to be active in extracellular space and secretory granule. Orthologous to human KLK14 (kallikrein related peptidase 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klk14 |
| Official Name | kallikrein related-peptidase 14 [Source:RGD Symbol;Acc:1308606] |
| Ensembl ID | ENSRNOG00000033706 |
| Bio databases IDs | |
| Aliases | kallikrein related-peptidase 14 |
| Synonyms | GK14, kallikrein related-peptidase 14, KLK-L6, Klnm |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klk14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Trypsin-like serine protease
- trypsin
- Tryp_SPc
- serine endopeptidase
- peptidase
- Trypsin-like peptidase domain
Pathways
Biological processes and signaling networks where the Klk14 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klk14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epidermis morphogenesis
- seminal clot liquefaction
- proteolysis
- fertilization
- negative regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of G-protein coupled receptor protein signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- secretory granule
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase activity