D2hgdh Gene Summary [Rat]
Enables (R)-2-hydroxyglutarate dehydrogenase activity. Involved in response to cobalt ion; response to manganese ion; and response to zinc ion. Located in mitochondrion. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 1. Orthologous to human D2HGDH (D-2-hydroxyglutarate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | D2hgdh |
| Official Name | D-2-hydroxyglutarate dehydrogenase [Source:RGD Symbol;Acc:1307976] |
| Ensembl ID | ENSRNOG00000019012 |
| Bio databases IDs | |
| Aliases | D-2-hydroxyglutarate dehydrogenase |
| Synonyms | AA408776, AA408778, D2HGD, D-2-hydroxyglutarate dehydrogenase, LOC257054, RGD1307976 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat D2hgdh often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- FAD binding domain
- zinc ion binding
- FAD linked oxidases, C-terminal domain
- CH-OH group oxidoreductase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- D-2-hydroxyglutaric aciduria type 1
- allergy
- asthma
- respiratory disorder
- hereditary disorder
- D-2-hydroxyglutaric aciduria
- eczema
- allergic rhinitis
- glioma
regulates
- 2-oxoglutaric acid
- malic acid
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat D2hgdh gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to manganese ion
- protein metabolic process
- malate metabolic process
- response to zinc ion
- response to calcium ion
- response to cobalt ion
- response to magnesium ion
- 2-oxoglutarate metabolic process
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- FAD binding
- zinc ion binding
- (R)-2-hydroxyglutarate dehydrogenase activity