Stom Gene Summary [Rat]
Predicted to enable RNA polymerase binding activity; ion channel inhibitor activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation by host of viral genome replication; positive regulation of protein targeting to membrane; and positive regulation of viral process. Predicted to be located in several cellular components, including membrane raft; mitochondrion; and perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Orthologous to human STOM (stomatin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stom |
| Official Name | stomatin [Source:RGD Symbol;Acc:1305109] |
| Ensembl ID | ENSRNOG00000019147 |
| Bio databases IDs | |
| Aliases | stomatin |
| Synonyms | BND7, EPB7, EPB72, EPB7.2, Stomatin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stom often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ion channel inhibitor
- SPFH_like
- prohibitin homologues
- enzyme binding
- protein homodimerization
- protein binding
- SPFH domain / Band 7 family
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- septic shock
- sickle cell anemia
- Huntington disease
- carcinoma in situ
- epithelial cancer in situ
- rheumatoid arthritis
- progressive supranuclear palsy
- Sengers syndrome
regulates
- GLUT1/3/4
role in cell
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- insoluble fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- intracellular membrane-bounded organelle
- cytoskeleton
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- secretory granule membrane
- granules
- tertiary granule membrane
- specific granule membrane
- cytosol
- cytoplasmic face of plasma membrane
- lysosome membrane
- alpha granule membranes
- alpha granules
- secretory vesicles
- membrane rafts
- exosomes
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stom gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein targeting to membrane
- regulation of ion transmembrane transport
- positive regulation of viral reproduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- plasma membrane
- extracellular space
- extracellular vesicular exosome
- cytoskeleton
- perinuclear region of cytoplasm
- melanosome
- blood microparticle
- membrane
- membrane raft
- mitochondrion
- vesicle
- azurophil granule membrane
- tertiary granule membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- RNA polymerase binding
- identical protein binding
- protein binding
- protein homodimerization activity
- ion channel inhibitor activity