Ngf Gene Summary [Rat]
Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; nervous system development; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin TRK receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study several diseases, including bladder neck obstruction; bone disease (multiple); middle cerebral artery infarction; neurogenic bladder; and overactive bladder syndrome. Biomarker of several diseases, including alcohol dependence; alcohol use disorder; borna disease; cryptorchidism; and hyperhomocysteinemia. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; interstitial cystitis; and opiate dependence (multiple). Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ngf |
| Official Name | nerve growth factor [Source:RGD Symbol;Acc:1598328] |
| Ensembl ID | ENSRNOG00000016571 |
| Bio databases IDs | |
| Aliases | nerve growth factor |
| Synonyms | 2.5S NGF, Beta-NGF, HSAN5, nerve growth factor, Nerve growth factor, β, NGFB, Ngf beta, Ngf β, β-nerve growth factor, β-NGF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ngf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nerve growth factor receptor binding
- transmembrane receptor protein tyrosine kinase activator
- receptor agonist activity
- protein binding
- caspase activator
- loop domain
- pro domain
- metalloendopeptidase inhibitor
- growth factor
- Nerve growth factor family
Pathways
Biological processes and signaling networks where the Ngf gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Axonal Guidance Signaling
- CDK5 Signaling
- Circadian Rhythm Signaling
- ERK5 Signaling
- Human Embryonic Stem Cell Pluripotency
- Huntington's Disease Signaling
- Macropinocytosis Signaling
- Neuroinflammation Signaling Pathway
- Neurotrophin/TRK Signaling
- NF-κB Signaling
- NGF Signaling
- PEDF Signaling
- Thyroid Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- neoplasia
- cognitive impairment
- weight loss
- knee osteoarthritis
- myocardial infarction
- cardiomyopathy
- hyperplasia
- low back pain
- hyperinsulinism
role in cell
- expression in
- quantity
- proliferation
- damage
- cell death
- cell viability
- apoptosis
- activity
- production in
- activation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- cell surface
- membrane surface
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- granules
- cytosol
- endoplasmic reticulum lumen
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ngf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- neuron projection morphogenesis
- positive regulation of neuron differentiation
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of Ras protein signal transduction
- positive regulation of DNA binding
- induction of apoptosis via death domain receptors
- nerve development
- negative regulation of neuron apoptotic process
- positive regulation of gene expression
- regulation of synaptic transmission
- positive regulation of peptidyl-serine phosphorylation
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- synaptic vesicle
- endosome lumen
- cytosol
- extracellular region
- Golgi lumen
- axon
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- nerve growth factor receptor binding
- lipid binding
- metalloendopeptidase inhibitor activity