Ptdss2 Gene Summary [Rat]
Predicted to enable CDP-diacylglycerol-serine O-phosphatidyltransferase activity and L-serine-phosphatidylethanolamine phosphatidyltransferase activity. Predicted to act upstream of or within phosphatidylserine biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human PTDSS2 (phosphatidylserine synthase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ptdss2 |
| Official Name | phosphatidylserine synthase 2 [Source:RGD Symbol;Acc:1307914] |
| Ensembl ID | ENSRNOG00000015912 |
| Bio databases IDs | |
| Aliases | phosphatidylserine synthase 2 |
| Synonyms | LOC100131598, phosphatidylserine synthase 2, PSS-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ptdss2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- substituted phosphate group transferase
- transferase
- CDPdiacylglycerol-serine O-phosphatidyltransferase
- L-serine-phosphatidylethanolamine phosphatidyltransferase
- Phosphatidyl serine synthase
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- HER2 negative hormone receptor negative breast cancer
- urothelial bladder carcinoma
- transitional cell bladder cancer
- epithelial cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- pancreatic adenocarcinoma
- pancreatic epithelial cancer
- epithelial uterine cancer
- salivary gland carcinoma
regulated by
- MAP4K4
- phosphatidylserine
regulates
- L-serine
- phosphatidylserine
role in cell
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular space
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- mitochondria-associated membranes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ptdss2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphatidylserine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
Molecular Function
What the gene product does at the molecular level
- transferase activity
- CDP-diacylglycerol-serine O-phosphatidyltransferase activity