Birc7 Gene Summary [Rat]
Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of protein ubiquitination; regulation of apoptotic process; and regulation of signal transduction. Predicted to act upstream of with a negative effect on regulation of apoptotic process. Predicted to act upstream of or within lens development in camera-type eye. Predicted to be located in several cellular components, including Golgi apparatus; centrosome; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human BIRC7 (baculoviral IAP repeat containing 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Birc7 |
| Official Name | baculoviral IAP repeat-containing 7 [Source:RGD Symbol;Acc:1562883] |
| Ensembl ID | ENSRNOG00000043311 |
| Bio databases IDs | |
| Aliases | baculoviral IAP repeat-containing 7 |
| Synonyms | baculoviral IAP repeat-containing 7, E130019N06, KIAP, LIVIN, ML-IAP, RGD1562883, RNF50 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Birc7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine protease inhibitor activity
- Bir domain
- BIR
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- enzyme
- Ring finger domain
- protein binding
- cleavage site
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Pathways
Biological processes and signaling networks where the Birc7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- superficial transitional cell carcinoma of the bladder
- transitional cell bladder cancer
- nonmuscle invasive bladder cancer
- melanoma
- melanoma cancer
- superficial bladder carcinoma
- bladder carcinoma
role in cell
- apoptosis
- migration
- expression in
- proliferation
- cell viability
- colony formation
- invasion
- cell death
- cellular infiltration by
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- centrosome
- Golgi Apparatus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Birc7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of tumor necrosis factor-mediated signaling pathway
- positive regulation of JNK cascade
- negative regulation of apoptotic process
- apoptotic process
- positive regulation of protein ubiquitination
- regulation of natural killer cell apoptotic process
- regulation of apoptotic process
- regulation of cell cycle
- lens development in camera-type eye
- regulation of cell proliferation
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- cysteine-type endopeptidase inhibitor activity
- metal ion binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- enzyme binding