Rbm22 Gene Summary [Rat]
Predicted to enable U6 snRNA binding activity; calcium-dependent protein binding activity; and pre-mRNA binding activity. Predicted to be involved in several processes, including mRNA cis splicing, via spliceosome; positive regulation of RNA splicing; and positive regulation of intracellular protein transport. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of Prp19 complex; U2-type catalytic step 1 spliceosome; and U2-type catalytic step 2 spliceosome. Orthologous to human RBM22 (RNA binding motif protein 22). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbm22 |
| Official Name | RNA binding motif protein 22 [Source:RGD Symbol;Acc:1305770] |
| Ensembl ID | ENSRNOG00000019235 |
| Bio databases IDs | |
| Aliases | RNA binding motif protein 22 |
| Synonyms | 8430430L24Rik, Cwc2, fSAP47, RNA binding motif protein 22, ZC3H16 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rbm22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- zinc finger
- RNA recognition motif (RRM) superfamily
- RNA recognition motif
- U6 snRNA binding
- protein binding
- zinc finger domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- catalytic step 2 spliceosome
- Cytoplasm
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rbm22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein import into nucleus
- nuclear mRNA cis splicing, via spliceosome
- positive regulation of protein export from nucleus
- positive regulation of RNA splicing
- cellular response to xenobiotic stimulus
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- U2-type catalytic step 1 spliceosome
- U2-type catalytic step 2 spliceosome
- Prp19 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA binding
- U6 snRNA binding
- RNA binding
- protein binding
- metal ion binding
- calcium-dependent protein binding