Pdcd6 Gene Summary [Rat]
Predicted to enable several functions, including metal ion binding activity; protein dimerization activity; and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including COPII vesicle coating; mesenchymal cell differentiation; and negative regulation of signal transduction. Predicted to act upstream of or within apoptotic process. Predicted to be located in several cellular components, including endoplasmic reticulum exit site; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of COPII vesicle coat and Cul3-RING ubiquitin ligase complex. Orthologous to human PDCD6 (programmed cell death 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pdcd6 |
| Official Name | programmed cell death 6 [Source:RGD Symbol;Acc:1311239] |
| Ensembl ID | ENSRNOG00000014485 |
| Bio databases IDs | |
| Aliases | programmed cell death 6 |
| Synonyms | ALG-2, LOC100129491, MA-3, PEF1B, programmed cell death 6, PS2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pdcd6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- protein dimerization
- calcium-dependent protein binding
- EF-hand, calcium binding motif
- dimerization domain
- EF-hand domain pair
- protein binding activity, bridging
- calcium ion binding
- EFh
- calcium binding loop
- protein binding
- magnesium ion binding
- identical protein binding
- EF hand like domain
- The penta-EF hand (PEF) family
- EF-hand domain
- EF hand
- protein homodimerization
- protein heterodimerization
- hydrophobic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hearing loss
- breast carcinoma
- small cell lung carcinoma
- small cell lung cancer
role in cell
- activation in
- accumulation in
- proliferation
- apoptosis
- binding in
- migration
- clustering
- quantity
- fusion
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- soluble fraction
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum exit sites
- nucleoplasm
- nucleoli
- cytoplasmic vesicles
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pdcd6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neural crest cell development
- apoptotic signaling pathway
- intracellular protein transport
- positive regulation of angiogenesis
- COPII vesicle coating
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
- ER to Golgi vesicle-mediated transport
- cellular response to heat
- angiogenesis
- response to calcium ion
- negative regulation of vascular endothelial growth factor receptor signaling pathway
- positive regulation of endothelial cell proliferation
- negative regulation of TOR signaling cascade
- positive regulation of endothelial cell migration
- neural crest formation
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum
- nucleoplasm
- endoplasmic reticulum membrane
- nucleus
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- endosome
- cytoplasm
- cytoplasmic vesicle
- cytosol
- endoplasmic reticulum exit site
- Cul3-RING ubiquitin ligase complex
- COPII vesicle coat
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- identical protein binding
- protein homodimerization activity
- protein binding
- protein heterodimerization activity
- calcium ion binding
- protein anchor
- calcium-dependent protein binding
- protein dimerization activity
- protein binding, bridging