Cfdp1 Gene Summary [Rat]
Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within several processes, including cell adhesion; negative regulation of fibroblast apoptotic process; and regulation of cell shape. Predicted to be located in kinetochore. Predicted to be part of Swr1 complex. Orthologous to human CFDP1 (craniofacial development protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cfdp1 |
| Official Name | craniofacial development protein 1 [Source:RGD Symbol;Acc:735080] |
| Ensembl ID | ENSRNOG00000019326 |
| Bio databases IDs | |
| Aliases | craniofacial development protein 1 |
| Synonyms | BCNT, BUCENTAUR, CENP-29, CFDP, CP27, craniofacial development protein 1, LOC101928178, p97, p97 HOMOLOGOUS, P97/VCP, SWC5, Yeti |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cfdp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Bucentaur or craniofacial development
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pain
- migraines
- coronary artery disease
- cardiovascular disorder
- chronic obstructive pulmonary disease
- abdominal aortic aneurysm
- cerebral aneurysm
- Dupuytren contracture
- angina pectoris
- irritable bowel syndrome
regulated by
- thioguanine nucleotide
- laduviglusib
- H2BC17
- PHR
regulates
role in cell
- proliferation
- apoptosis
- degradation in
- 5-fluorouracil resistance
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cfdp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of fibroblast apoptotic process
- regulation of cell shape
- chromatin remodeling
- cell adhesion
- fibroblast apoptotic process
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- Swr1 complex
- kinetochore