Klhl40 Gene Summary [Rat]
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of protein metabolic process; and skeletal muscle fiber development. Predicted to act upstream of or within skeletal muscle fiber differentiation. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in A band and I band. Human ortholog(s) of this gene implicated in nemaline myopathy 8. Orthologous to human KLHL40 (kelch like family member 40). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klhl40 |
| Official Name | kelch-like family member 40 [Source:RGD Symbol;Acc:1305368] |
| Ensembl ID | ENSRNOG00000019390 |
| Bio databases IDs | |
| Aliases | kelch-like family member 40 |
| Synonyms | 2310024D23Rik, KBTBD5, kelch-like 40, kelch-like family member 40, LOC686128, NEM8, SRYP, SYRP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Klhl40 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Galactose oxidase, central domain
- Kelch motif
- BTB And C-terminal Kelch
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- Kelch domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- sarcomere
- I band
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Klhl40 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- skeletal muscle fiber development
- positive regulation of protein ubiquitination
- negative regulation of protein ubiquitination
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- I band
- A band
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- protein binding