Tnnt1 Gene Summary [Rat]
Enables troponin T binding activity. Involved in slow-twitch skeletal muscle fiber contraction. Part of troponin complex. Human ortholog(s) of this gene implicated in nemaline myopathy 5A; nemaline myopathy 5B; and nemaline myopathy 5C. Orthologous to human TNNT1 (troponin T1, slow skeletal type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnnt1 |
| Official Name | troponin T1, slow skeletal type [Source:RGD Symbol;Acc:621852] |
| Ensembl ID | ENSRNOG00000028041 |
| Bio databases IDs | |
| Aliases | troponin T1, slow skeletal type |
| Synonyms | ANM, Fang2, NEM5, SLOW SKELETAL TROPONIN T1, Slow tnt, ssTnT, STNT, TNT, TNTS, troponin T1, skeletal, slow, troponin T1, slow skeletal type |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnnt1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Troponin
- cytoskeletal protein binding
- tropomyosin binding
- protein binding
Pathways
Biological processes and signaling networks where the Tnnt1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- Amish type nemaline myopathy
- liver cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- breast carcinoma
- Huntington disease
regulates
- p38 MAPK
- JINK1/2
- CACNA1S
role in cell
- migration
- proliferation
- diameter
- invasion by
- contraction
- abnormal morphology
- epithelial-mesenchymal transition in
- size
- contractility
- atrophy
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnnt1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transition between fast and slow fiber
- skeletal muscle contraction
- sarcomere organization
- slow-twitch skeletal muscle fiber contraction
- negative regulation of muscle contraction
Cellular Component
Where in the cell the gene product is active
- cytosol
- troponin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- troponin T binding
- tropomyosin binding