Adcyap1 Gene Summary [Rat]
Enables neuropeptide hormone activity; pituitary adenylate cyclase activating polypeptide activity; and pituitary adenylate cyclase-activating polypeptide receptor binding activity. Involved in several processes, including negative regulation of acute inflammatory response; positive regulation of cell communication; and positive regulation of macromolecule metabolic process. Located in extracellular space and terminal bouton. Is active in neuronal dense core vesicle lumen. Used to study Parkinsonism and acute necrotizing pancreatitis. Biomarker of cystitis. Human ortholog(s) of this gene implicated in alcohol dependence. Orthologous to human ADCYAP1 (adenylate cyclase activating polypeptide 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcyap1 |
| Official Name | adenylate cyclase activating polypeptide 1 [Source:RGD Symbol;Acc:2037] |
| Ensembl ID | ENSRNOG00000049882 |
| Bio databases IDs | |
| Aliases | adenylate cyclase activating polypeptide 1 |
| Synonyms | adenylate cyclase activating polypeptide 1, PACAP, PACAP27, PCAP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adcyap1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Peptide hormone
- G-protein-coupled receptor binding
- pituitary adenylate cyclase activating polypeptide
- protein binding
- receptor binding
- neuropeptide hormone
Pathways
Biological processes and signaling networks where the Adcyap1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- microvesicular hepatic steatosis
- apnea
- hypoglycemia
- hyperthermia
- hyperactive behavior
- hypophagia
- cognitive impairment
- wasting
- neurological deficiency
- epileptic seizure
role in cell
- disorganization
- expression in
- activation in
- quantity
- production in
- migration
- accumulation in
- phosphorylation in
- length
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- membrane fraction
- secretory granule lumen
- Cytoplasm
- vesicles
- cytosol
- acrosome
- neurites
- secretory granules
- perikaryon
- axons
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adcyap1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of growth hormone secretion
- insulin secretion
- regulation of protein localization
- neuron projection development
- negative regulation of cell cycle
- cell-cell signaling
- female pregnancy
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of GTPase activity
- elevation of cytosolic calcium ion concentration
- neuropeptide signaling pathway
- positive regulation of chemokine (C-C motif) ligand 5 production
- positive regulation of protein kinase activity
- positive regulation of ERK1 and ERK2 cascade
- activation of adenylate cyclase activity
- cAMP-mediated signaling
Cellular Component
Where in the cell the gene product is active
- extracellular region
- perikaryon
- neuron projection
Molecular Function
What the gene product does at the molecular level
- protein binding
- neuropeptide hormone activity
- peptide hormone receptor binding
- pituitary adenylate cyclase activating polypeptide activity
- receptor binding