Ghr Gene Summary [Rat]
Enables SH2 domain binding activity; enzyme binding activity; and growth hormone receptor activity. Involved in several processes, including activation of Janus kinase activity; cell surface receptor signaling pathway via JAK-STAT; and cellular response to peptide hormone stimulus. Located in extracellular space and neuronal cell body. Biomarker of congenital hypothyroidism; muscular atrophy; osteopetrosis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Laron syndrome; familial hypercholesterolemia; isolated growth hormone deficiency; osteoarthritis; and type 2 diabetes mellitus. Orthologous to human GHR (growth hormone receptor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ghr |
| Official Name | growth hormone receptor [Source:RGD Symbol;Acc:2687] |
| Ensembl ID | ENSRNOG00000015654 |
| Bio databases IDs | |
| Aliases | growth hormone receptor |
| Synonyms | Ghbp, GHIP, GHR/BP, GROWTH HORMONE receptor |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ghr often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signal peptide
- Fibronectin type 3 domain
- identical protein binding
- proline rich domain
- polypeptide hormone binding
- YXXP domain
- Box I domain
- Jak2 binding domain
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- tail domain
- membrane-proximal domain
- transmembrane receptor
- growth factor binding
- extracellular domain
- dimerization domain
- lipid binding
- protein kinase binding
- growth hormone receptor
- SH2-domain binding
- protein phosphatase binding
- protein binding
- protein tyrosine kinase activator
- phosphorylation site
- FN3
- transmembrane domain
- protein homodimerization
- growth hormone receptor binding
- tyrosine phosphorylation site
Pathways
Biological processes and signaling networks where the Ghr gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cognitive impairment
- insulin-dependent diabetes mellitus
- epithelial cancer
- epithelial neoplasia
- adenoma formation
- benign neoplasia
- growth hormone deficiency
- dwarfism
- acromegaly
- hypothyroidism
role in cell
- proliferation
- apoptosis
- activation
- expression in
- cell death
- signaling in
- morphology
- growth
- differentiation
- association
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- cytosol
- caveolar membranes
- membrane rafts
- perikaryon
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ghr gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- growth hormone receptor signaling pathway
- response to food
- positive regulation of MAP kinase activity
- regulation of multicellular organism growth
- cartilage development involved in endochondral bone morphogenesis
- insulin-like growth factor receptor signaling pathway
- positive regulation of cell differentiation
- positive regulation of tyrosine phosphorylation of STAT protein
- endocytosis
- hormone metabolic process
- positive regulation of multicellular organism growth
- JAK-STAT cascade
- positive regulation of JAK-STAT cascade
- hormone-mediated signaling pathway
- cellular response to insulin stimulus
- response to gravity
- cytokine-mediated signaling pathway
- response to glucocorticoid stimulus
- response to interleukin-1
- taurine metabolic process
- cellular response to hormone stimulus
- regulation of response to nutrient levels
- positive regulation of peptidyl-tyrosine phosphorylation
Cellular Component
Where in the cell the gene product is active
- growth hormone receptor complex
- extracellular space
- membrane
- external side of plasma membrane
- cytosol
- receptor complex
- neuronal cell body
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- growth factor binding
- identical protein binding
- protein homodimerization activity
- protein phosphatase binding
- lipid binding
- SH2 domain binding
- proline-rich region binding
- protein binding
- growth hormone receptor activity
- peptide hormone binding
- cytokine binding