Sgta Gene Summary [Mouse]
Predicted to enable BAT3 complex binding activity; molecular adaptor activity; and protein dimerization activity. Predicted to be involved in several processes, including establishment of protein localization to membrane; protein complex oligomerization; and regulation of proteolysis involved in protein catabolic process. Predicted to be located in cytosol and nucleus. Predicted to be part of TRC complex. Predicted to be active in membrane and presynapse. Predicted to be extrinsic component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and skin. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgta |
| Official Name | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha [Source:MGI Symbol;Acc:MGI:1098703] |
| Ensembl ID | ENSMUSG00000004937 |
| Bio databases IDs | |
| Aliases | small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha |
| Synonyms | 5330427H01Rik, alphaSGT, D10Ertd190e, hSGT, SGT, SGT1, small glutamine rich tetratricopeptide repeat co-chaperone alpha, small glutamine rich tetratricopeptide repeat co-chaperone α, small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha, small glutamine-rich tetratricopeptide repeat (TPR)-containing, α, Stg, Vpu, Vpu-binding |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sgta often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- binding protein
- Tetratricopeptide repeats
- Homodimerization domain of SGTA
- protein homodimerization
- protein binding
- tetratricopeptide repeat
- identical protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosolic synaptosomal fraction
- presynaptic regions
- cellular membrane
- Nucleus
- vesicles
- cytosol
- nucleoplasm
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sgta gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- tail-anchored membrane protein insertion into ER membrane
- posttranslational protein targeting to membrane
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- TRC complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- binding, bridging