Coasy Gene Summary [Rat]
Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coasy |
| Official Name | Coenzyme A synthase [Source:RGD Symbol;Acc:1549767] |
| Ensembl ID | ENSRNOG00000019918 |
| Bio databases IDs | |
| Aliases | Coenzyme A synthase |
| Synonyms | 1300003G02Rik, CoA synthase, Coenzyme A synthase, DPCK, Naglu, NBIA6, NBP, PCH12, pOV-2, PPAT, PPAT/DPCK, UKR1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Coasy often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-N-acetylglucosaminidase
- dephospho-CoA kinase
- Cytidylyltransferase-like
- Cytidylate kinase-like family
- NK
- cytidyltransferase-like domain
- pantetheine-phosphate adenylyltransferase
- enzyme
- protein binding
- nucleotidyl transferase superfamily
- AAA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration with brain iron accumulation 6
- pontocerebellar hypoplasia type 12
- neurodegeneration with brain iron accumulation
- myopathy with abnormal lipid metabolism
- aortic valve calcification
- infection by HIV-1
regulates
- coenzyme A
role in cell
- function
- function in
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Coasy gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- coenzyme A biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- dephospho-CoA kinase activity
- pantetheine-phosphate adenylyltransferase activity