Coasy Gene Summary [Mouse]
This gene encodes the bifunctional protein coenzyme A (CoA) synthase which carries out the last two steps in the biosynthesis of CoA from pantothenic acid (vitamin B5). The phosphopantetheine adenylyltransferase domain of this protein catalyzes the conversion of phosphopantetheine into dephospho-CoA while its dephospho-CoA kinase domain completes the final step by phosphorylating dephospho-CoA to form CoA. [provided by RefSeq, Apr 2015]
Details
| Type | Protein Coding |
| Official Symbol | Coasy |
| Official Name | Coenzyme A synthase [Source:MGI Symbol;Acc:MGI:1918993] |
| Ensembl ID | ENSMUSG00000001755 |
| Bio databases IDs | |
| Aliases | Coenzyme A synthase |
| Synonyms | 1300003G02Rik, CoA synthase, Coenzyme A synthase, DPCK, Naglu, NBIA6, NBP, PCH12, pOV-2, PPAT, PPAT/DPCK, UKR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coasy often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- alpha-N-acetylglucosaminidase
- dephospho-CoA kinase
- Cytidylyltransferase-like
- Cytidylate kinase-like family
- NK
- cytidyltransferase-like domain
- pantetheine-phosphate adenylyltransferase
- enzyme
- protein binding
- nucleotidyl transferase superfamily
- AAA domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration with brain iron accumulation 6
- pontocerebellar hypoplasia type 12
- neurodegeneration with brain iron accumulation
- myopathy with abnormal lipid metabolism
- aortic valve calcification
- infection by HIV-1
regulates
- coenzyme A
role in cell
- function
- function in
- cisplatin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coasy gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- coenzyme A biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- mitochondrial matrix
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- dephospho-CoA kinase activity
- pantetheine-phosphate adenylyltransferase activity