Krt20 Gene Summary [Rat]
Predicted to enable structural molecule activity. Predicted to be involved in several processes, including cellular response to starvation; intermediate filament organization; and regulation of protein secretion. Predicted to be located in cytosol and intermediate filament cytoskeleton. Predicted to be active in cytoskeleton. Orthologous to human KRT20 (keratin 20). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt20 |
| Official Name | keratin 20 [Source:RGD Symbol;Acc:628646] |
| Ensembl ID | ENSRNOG00000027139 |
| Bio databases IDs | |
| Aliases | keratin 20 |
| Synonyms | 9030623C06RIK, CD20, CK-20, CYTOKERATIN20, K20, KER20, keratin 20, KRT21 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Krt20 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Intermediate filament protein
- Apolipoprotein A1/A4/E domain
Pathways
Biological processes and signaling networks where the Krt20 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- squamous cell cancer
- follicular thyroid cancer
- liver cancer
- colorectal cancer
- breast carcinoma
- T-cell/histiocyte rich large B-cell lymphoma
- de novo diffuse large B-cell lymphoma
- relapsing multiple sclerosis
- relapsing-remitting multiple sclerosis
role in cell
- organization
- maturation
- response
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- intermediate filament cytoskeleton
- cytosol
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Krt20 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- regulation of protein secretion
- apoptotic process
- cellular response to starvation
- intermediate filament organization
Cellular Component
Where in the cell the gene product is active
- cytoskeleton
- intermediate filament cytoskeleton
- cytoplasm
- cytosol
- intermediate filament
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural constituent of cytoskeleton