Slc7a6 Gene Summary [Rat]
Predicted to enable L-lysine:L-arginine antiporter activity and arginine binding activity. Involved in L-arginine transmembrane transport and nitric oxide biosynthetic process. Predicted to be located in plasma membrane. Orthologous to human SLC7A6 (solute carrier family 7 member 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc7a6 |
| Official Name | solute carrier family 7 member 6 [Source:RGD Symbol;Acc:1309193] |
| Ensembl ID | ENSRNOG00000019943 |
| Bio databases IDs | |
| Aliases | solute carrier family 7 member 6 |
| Synonyms | AI643885, KIAA0245, LAT-2, LAT3, Slc7a6 predicted, solute carrier family 7 (cationic amino acid transporter, y+ system), member 6, solute carrier family 7 member 6, Y+LAT2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Slc7a6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transporter, basic amino acid/polyamine antiporter (APA) family
- L-amino acid transporter
- protein binding
- basic amino acid transporter
- amino acid binding
- organic cation transporter
- amino acid permease (yeast)
- binding protein
- lysine transporter
- amino acid permease
- antiporter
- L-type amino acid transporter
- amino acid transporter
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- otosclerosis
- prostate cancer
- amyotrophic lateral sclerosis
regulates
- L-ornithine
- L-arginine
- neutral amino acid
- SLC7A6
- nitric oxide
- MIR2682
- amino acids
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Slc7a6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycine betaine transport
- neutral amino acid transport
- nitric oxide biosynthetic process
- ornithine transport
- amino acid transmembrane transport
- leucine transport
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- arginine binding
- L-amino acid transmembrane transporter activity
- protein binding
- basic amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity