Scn3b Gene Summary [Rat]
Predicted to enable sodium channel inhibitor activity; transmembrane transporter binding activity; and voltage-gated sodium channel activity involved in cardiac muscle cell action potential. Involved in nervous system development and sodium ion transport. Predicted to be located in several cellular components, including Z disc; cytosol; and plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Human ortholog(s) of this gene implicated in Brugada syndrome 7. Orthologous to human SCN3B (sodium voltage-gated channel beta subunit 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Scn3b |
| Official Name | sodium voltage-gated channel beta subunit 3 [Source:RGD Symbol;Acc:621657] |
| Ensembl ID | ENSRNOG00000057221 |
| Bio databases IDs | |
| Aliases | sodium voltage-gated channel beta subunit 3 |
| Synonyms | 1110001K16Rik, 4833414B02Rik, ATFB16, BRGDA7, HSA243396, KIAA1158, SCNB3, sodium channel, voltage-gated, type III, beta, sodium channel, voltage-gated, type III, β, sodium voltage-gated channel beta subunit 3, sodium voltage-gated channel β subunit 3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Scn3b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- voltage-gated sodium channel
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- ion channel binding
- sodium channel regulator
- protein binding
- ion channel
- Immunoglobulin V-set domain
Pathways
Biological processes and signaling networks where the Scn3b gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- migraines
- epilepsy
- weight gain
- amyotrophic lateral sclerosis
- localization-related epilepsy
- schizophrenia
- Huntington disease
- obesity
- familial atrial fibrillation
regulates
- Na+
- SCN3A
role in cell
- apoptosis
- colony formation
- depolarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- intracellular membrane-bounded organelle
- Cytoplasm
- cellular membrane
- Endoplasmic Reticulum
- cytosol
- Z line
- membrane rafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Scn3b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cardiac muscle cell action potential involved in contraction
- positive regulation of heart rate
- regulation of atrial cardiac muscle cell action potential
- membrane depolarization involved in regulation of cardiac muscle cell action potential
- regulation of atrial cardiomyocyte membrane depolarization
- regulation of SA node cardiac muscle cell action potential
- regulation of ventricular cardiac muscle cell action potential
- regulation of ventricular cardiomyocyte membrane depolarization
- nervous system development
- cardiac muscle contraction
- sodium ion transport
- regulation of sodium ion transmembrane transporter activity
- positive regulation of sodium ion transport
- sodium ion transmembrane transport
- regulation of heart rate by cardiac conduction
- membrane depolarization
- membrane depolarization involved in regulation of action potential
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- Z disc
- membrane
- voltage-gated sodium channel complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- sodium channel regulator activity
- protein binding
- voltage-gated sodium channel activity involved in regulation of cardiac muscle cell action potential
- sodium channel inhibitor activity
- ion channel binding