Nt5c2 Gene Summary [Rat]
Enables 5'-nucleotidase activity. Involved in adenosine metabolic process and purine nucleoside monophosphate metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 45. Orthologous to human NT5C2 (5'-nucleotidase, cytosolic II). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nt5c2 |
| Official Name | 5'-nucleotidase, cytosolic II [Source:RGD Symbol;Acc:2323387] |
| Ensembl ID | ENSRNOG00000020179 |
| Bio databases IDs | |
| Aliases | 5'-nucleotidase, cytosolic II |
| Synonyms | 2010002I23Rik, 5'-nucleotidase, cytosolic II, cN-II, Gm9751, GMP, LOC100363253, NT5B, PNT5, SPG45, SPG65 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nt5c2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleoside phosphotransferase
- HAD superfamily (subfamily IG) hydrolase, 5'-nucleotidase
- 5'-nucleotidase
- 5' nucleotidase family
- ubiquitin protein ligase activity
- ATP binding
- phosphatase
- protein binding
- identical protein binding
- Haloacid Dehalogenase-like Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- depressive disorder
- myocardial infarction
- systemic lupus erythematosus
- non-insulin-dependent diabetes mellitus
- hypertension
- cardiovascular disorder
- autosomal recessive spastic paraplegia type 45
- metabolic syndrome X
- migraines
regulates
- D-glucose
- glycogen
- allantoin
- xanthosine monophosphate
- palmitic acid
- lactic acid
- 2-deoxyglucose
- GMP
- xanthosine
- guanosine
role in cell
- phosphorylation in
- transport in
- cell death
- oxidation in
- incorporation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nt5c2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dGMP metabolic process
- IMP metabolic process
- protein K48-linked ubiquitination
- adenosine metabolic process
- GMP metabolic process
- negative regulation of defense response to virus by host
- IMP catabolic process
- allantoin metabolic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding
- nucleoside phosphotransferase activity
- metal ion binding
- 5'-nucleotidase activity
- GMP 5'-nucleotidase activity
- IMP 5'-nucleotidase activity