Smyd1 Gene Summary [Rat]
Predicted to enable transcription corepressor activity. Predicted to be involved in positive regulation of myoblast differentiation and positive regulation of myotube differentiation. Predicted to act upstream of or within several processes, including chromatin remodeling; negative regulation of DNA-templated transcription; and skeletal muscle cell differentiation. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human SMYD1 (SET and MYND domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Smyd1 |
| Official Name | SET and MYND domain containing 1 [Source:RGD Symbol;Acc:1305105] |
| Ensembl ID | ENSRNOG00000006776 |
| Bio databases IDs | |
| Aliases | SET and MYND domain containing 1 |
| Synonyms | 4632404M21Rik, BOP, KMT3D, SET and MYND domain containing 1, ZMYND18, ZMYND22 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Smyd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- MYND finger
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- transcription co-repressor
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetic nephropathy
- hypoplasia
- growth failure
- single ventricle defect
role in cell
- expression in
- apoptosis
- differentiation
- maturation
- remodeling
- transactivation in
- state 3 respiration in
- mitochondrial respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Smyd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart development
- chromatin remodeling
- skeletal muscle cell differentiation
- negative regulation of transcription, DNA-dependent
- positive regulation of myotube differentiation
- positive regulation of myoblast differentiation
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding
- transcription corepressor activity