Tinf2 Gene Summary [Rat]
Predicted to enable telomeric DNA binding activity. Predicted to be involved in several processes, including negative regulation of telomere maintenance via telomerase; protein localization to chromosome, telomeric region; and telomere organization. Predicted to act upstream of or within negative regulation of telomere maintenance. Predicted to be located in chromosome, telomeric region; nuclear body; and perinucleolar chromocenter. Predicted to be part of shelterin complex. Human ortholog(s) of this gene implicated in Revesz syndrome and autosomal dominant dyskeratosis congenita 3. Orthologous to human TINF2 (TERF1 interacting nuclear factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tinf2 |
| Official Name | TERF1 interacting nuclear factor 2 [Source:RGD Symbol;Acc:1359192] |
| Ensembl ID | ENSRNOG00000020189 |
| Bio databases IDs | |
| Aliases | TERF1 interacting nuclear factor 2 |
| Synonyms | D14Wsu146e, DKCA3, TERF1 interacting nuclear factor 2, Terf1 (TRF1)-interacting nuclear factor 2, TIN2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tinf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TIN2_N
- HP1 binding domain
- protein binding
- telomeric DNA binding
- TRF1 interaction domain
Pathways
Biological processes and signaling networks where the Tinf2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant dyskeratosis congenita type 3
- dyskeratosis congenita
- non-small cell lung carcinoma
- non-small cell lung cancer
- long telomere syndrome
- pancytopenia
- Revesz syndrome
role in cell
- proliferation
- production in
- recruitment in
- cohesion
- anaphase
- assembly
- fusion
- length
- cohesion in
- shortening
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- Mitochondria
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
- nuclear matrix
- telomeres
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tinf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of epithelial cell proliferation
- negative regulation of protein ADP-ribosylation
- protein localization to chromosome, telomeric region
- telomere assembly
- negative regulation of telomere maintenance via telomerase
- telomere capping
- positive regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- chromosome, telomeric region
- nuclear body
- perinucleolar chromocenter
- telosome
- nuclear matrix
- nucleoplasm
- nuclear telomere cap complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- telomeric DNA binding