Terf1 Gene Summary [Rat]
Predicted to enable several functions, including DNA binding activity; ankyrin repeat binding activity; and protein homodimerization activity. Predicted to contribute to telomerase activity. Involved in response to xenobiotic stimulus. Predicted to be located in chromosome, telomeric region; nuclear lumen; and spindle. Predicted to be part of shelterin complex. Orthologous to human TERF1 (telomeric repeat binding factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Terf1 |
| Official Name | telomeric repeat binding factor 1 [Source:RGD Symbol;Acc:1311574] |
| Ensembl ID | ENSRNOG00000007291 |
| Bio databases IDs | |
| Aliases | telomeric repeat binding factor 1 |
| Synonyms | hTRF1-AS, PIN2, telomeric repeat binding factor 1, TRBF1, TRF, TRF1, t-TRF1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Terf1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- dimerization domain
- DNA binding domain
- nuclear localization sequence
- DNA bending protein
- protein domain specific binding
- enzyme
- protein binding
- sequence-specific DNA binding
- identical protein binding
- acidic domain
- telomeric DNA binding
- microtubule binding
- double-stranded telomeric DNA binding
- single-stranded DNA binding
- tankyrase binding domain
- Myb-like DNA-binding domain
- serine phosphorylation site
- protein homodimerization
- TRFH
- telomerase
Pathways
Biological processes and signaling networks where the Terf1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial neoplasia
- epithelial cancer
- dysplasia
- hyperpigmentation
- non-small cell lung cancer
- bleomycin-induced pulmonary fibrosis
- pneumonitis
- squamous cell cancer
role in cell
- phosphorylation in
- formation
- growth
- apoptosis
- binding in
- formation in
- proliferation
- cell cycle progression
- cytokinesis
- polymerization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- fibrillar center
- spindle apparatus
- intranuclear region
- microtubules
- nuclear foci
- chromosome
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear rim
- nuclear speckles
- mitotic spindle
- telomeres
- chromatin
- chromosomal bouquet
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Terf1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- meiotic telomere clustering
- telomere maintenance via telomerase
- telomere maintenance
- telomere capping
- negative regulation of DNA replication
- negative regulation of telomere maintenance via telomerase
- positive regulation of telomere maintenance
- negative regulation of telomerase activity
- negative regulation of telomere maintenance via semi-conservative replication
Cellular Component
Where in the cell the gene product is active
- nucleus
- chromosome, telomeric region
- nuclear body
- cytoplasm
- telosome
- spindle
- nucleolus
- fibrillar center
- nucleoplasm
- nuclear telomere cap complex
Molecular Function
What the gene product does at the molecular level
- telomerase activity
- DNA binding
- identical protein binding
- protein homodimerization activity
- protein binding
- telomeric DNA binding
- double-stranded telomeric DNA binding
- DNA binding, bending
- ankyrin repeat binding
- microtubule binding