Dlgap4 Gene Summary [Rat]
Enables protein domain specific binding activity. Predicted to be involved in modification of postsynaptic structure; modulation of chemical synaptic transmission; and regulation of synapse maturation. Located in dendrite and neuronal cell body. Orthologous to human DLGAP4 (DLG associated protein 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlgap4 |
| Official Name | DLG associated protein 4 [Source:RGD Symbol;Acc:708350] |
| Ensembl ID | ENSRNOG00000020225 |
| Bio databases IDs | |
| Aliases | DLG associated protein 4 |
| Synonyms | BC024558, DAP-4, DLG associated protein 4, DLP4, KIAA0964, SAPAP-4, WBP16, XIG3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlgap4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein domain specific binding
- protein binding
- Guanylate-kinase-associated protein (GKAP) protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- epithelial cancer
- epithelial basal cell carcinoma
- neuroblastoma
- neuroblastoma formation
- non-melanoma skin cancer
- arthropathy
- brain heterotopia
- uterine leiomyoma
- leiomyomatosis
role in cell
- maturation
- proliferation
- migration
- morphology
- dynamics
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- organelle
- cellular membrane
- neuromuscular junctions
- synapse
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlgap4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signaling
Cellular Component
Where in the cell the gene product is active
- neuromuscular junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- binding, bridging