Dlgap4 Gene Summary [Mouse]

This gene encodes a membrane-associated guanylate kinase found at the postsynaptic density in neuronal cells. The encoded protein may play a role in synapse organization and neuronal signalling. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Mar 2013]

Details

Type
Protein Coding
Official Symbol
Dlgap4
Official Name
DLG associated protein 4 [Source:MGI Symbol;Acc:MGI:2138865]
Ensembl ID
ENSMUSG00000061689
Bio databases IDs NCBI: 228836 Ensembl: ENSMUSG00000061689
Aliases DLG associated protein 4
Synonyms BC024558, DAP-4, DLG associated protein 4, DLP4, KIAA0964, SAPAP-4, WBP16, XIG3
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dlgap4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein domain specific binding
  • protein binding
  • Guanylate-kinase-associated protein (GKAP) protein

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • cancer
  • epithelial cancer
  • epithelial basal cell carcinoma
  • neuroblastoma
  • neuroblastoma formation
  • non-melanoma skin cancer
  • arthropathy
  • brain heterotopia
  • uterine leiomyoma
  • leiomyomatosis
regulated by
role in cell
  • maturation
  • proliferation
  • migration
  • morphology
  • dynamics

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • glutaminergic synapse
  • organelle
  • cellular membrane
  • neuromuscular junctions
  • synapse
  • perikaryon
  • dendrites

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Dlgap4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • signaling

Cellular Component

Where in the cell the gene product is active
  • neuromuscular junction
  • plasma membrane

Molecular Function

What the gene product does at the molecular level
  • protein binding
  • binding, bridging

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.