Dlg3 Gene Summary [Rat]
Enables PDZ domain binding activity; ionotropic glutamate receptor binding activity; and protein phosphatase binding activity. A structural constituent of postsynaptic density. Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; protein localization to synapse; and receptor clustering. Predicted to act upstream of or within establishment of planar polarity. Located in several cellular components, including dendritic shaft; growth cone; and postsynaptic density. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 90. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlg3 |
| Official Name | discs large MAGUK scaffold protein 3 [Source:RGD Symbol;Acc:68423] |
| Ensembl ID | ENSRNOG00000002767 |
| Bio databases IDs | |
| Aliases | discs large MAGUK scaffold protein 3 |
| Synonyms | discs large MAGUK scaffold protein 3, DLGH3, KIAA1232, mKIAA1232, MRX, MRX90, NEDLG, Neuroendocrine-DLG, PPP1R82, SAP102, XLID90, XLMR |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlg3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- Domain present in PSD-95, Dlg, and ZO-1/2
- protein phosphatase binding
- canonical PDZ domain
- protein domain specific binding
- protein binding
- PDZ domain
- ionotropic glutamate receptor binding
- PDZ-domain binding
- Src Homology 3 domain superfamily
- kinase
- guanylate kinase
- kinase binding
- Polyubiquitination (PEST) N-terminal domain of MAGUK
- NK
- guanylate kinase-like domain
- structural molecule
- cpPDZ_Deg_HtrA-like
- PDZ-associated domain of NMDA receptors
- phosphatase binding
Pathways
Biological processes and signaling networks where the Dlg3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- bipolar I disorder
- nonsyndromic X-linked mental retardation
- hereditary disorder
- major depression
- schizophrenia
- x-linked mental retardation type 90
- bipolar disorder
- mental retardation
role in cell
- growth
- expression in
- signaling in
- migration
- fragmentation
- fragmentation in
- development
- formation
- formation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- postsynaptic density (PSD) fractions
- membrane fraction
- glutaminergic synapse
- organelle
- Cytoplasm
- cellular membrane
- intercellular junctions
- cell-cell contacts
- cytosol
- basolateral cell surfaces
- postsynaptic membrane
- dendritic spines
- growth cone
- synaptosomes
- synapse
- tight junctions
- membrane rafts
- perikaryon
- dendrites
- postsynaptic density
- dendritic shafts
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlg3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- establishment or maintenance of epithelial cell apical/basal polarity
- negative regulation of cell proliferation
- positive regulation of protein tyrosine kinase activity
- establishment of planar polarity
- synaptic transmission
- receptor clustering
- receptor localization to synapse
Cellular Component
Where in the cell the gene product is active
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex
- adherens junction
- tight junction
- extracellular space
- cytosol
- neuromuscular junction
- basolateral plasma membrane
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatase binding
- protein kinase binding
- ionotropic glutamate receptor binding
- ubiquitin protein ligase binding
- protein binding
- kinase binding