Dcst1 Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of type I interferon-mediated signaling pathway; sperm-egg recognition; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within fusion of sperm to egg plasma membrane involved in single fertilization. Predicted to be located in plasma membrane. Orthologous to human DCST1 (DC-STAMP domain containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dcst1 |
| Official Name | DC-STAMP domain containing 1 [Source:RGD Symbol;Acc:1307756] |
| Ensembl ID | ENSRNOG00000020621 |
| Bio databases IDs | |
| Aliases | DC-STAMP domain containing 1 |
| Synonyms | A330106H01Rik, DC-STAMP domain containing 1, RGD1307756, SNKY, SPE49 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dcst1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase activity
- DC-STAMP-like protein
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Plasma Membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dcst1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm-egg recognition
- innate immune response
- negative regulation of type I interferon-mediated signaling pathway
- fusion of sperm to egg plasma membrane
- protein ubiquitination
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- acrosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding