Adcy3 Gene Summary [Rat]
Enables calcium- and calmodulin-responsive adenylate cyclase activity. Involved in cAMP biosynthetic process and cellular response to forskolin. Located in several cellular components, including apical cytoplasm; dendritic knob; and sperm midpiece. Part of ciliary necklace. Biomarker of cardiomyopathy and diabetes mellitus. Orthologous to human ADCY3 (adenylate cyclase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adcy3 |
| Official Name | adenylate cyclase 3 [Source:RGD Symbol;Acc:71009] |
| Ensembl ID | ENSRNOG00000003999 |
| Bio databases IDs | |
| Aliases | adenylate cyclase 3 |
| Synonyms | AC3, AC-III, adenylate cyclase 3, BMIQ19, mKIAA0511 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Adcy3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- adenylate cyclase
- calcium/calmodulin-responsive adenylate cyclase
- Class III nucleotidyl cyclases
- enzyme
- Adenylyl- / guanylyl cyclase, catalytic domain
Pathways
Biological processes and signaling networks where the Adcy3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Apelin Adipocyte Signaling Pathway
- Apelin Endothelial Signaling Pathway
- Cardiac β-adrenergic Signaling
- CDK5 Signaling
- Cellular Effects of Sildenafil (Viagra)
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- Docosahexaenoic Acid (DHA) Signaling
- Dopamine Receptor Signaling
- Dopamine-DARPP32 Feedback in cAMP Signaling
- Endocannabinoid Cancer Inhibition Pathway
- Endocannabinoid Developing Neuron Pathway
- Endothelin-1 Signaling
- eNOS Signaling
- Gustation Pathway
- Hepatic Cholestasis
- IL-1 Signaling
- Leptin Signaling in Obesity
- Melanocyte Development and Pigmentation Signaling
- P2Y Purinergic Receptor Signaling Pathway
- PPARα/RXRα Activation
- Protein Kinase A Signaling
- Renin-Angiotensin Signaling
- Thrombin Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- type 2 diabetic obesity
- obesity
- Crohn disease
- morbid obesity
- inflammatory bowel disease
- susceptibility to obesity type BMIQ19
- breast carcinoma
- monogenic obesity
- multiple sclerosis
regulates
- reactive oxygen species
- cyclic AMP
- MMP2
role in cell
- proliferation
- migration
- formation
- invasion
- growth
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- caveolae fraction
- Cytoplasm
- cilia
- perinuclear region
- cellular membrane
- Nucleus
- Golgi Apparatus
- apical cytoplasm
- sperm midpiece
- acrosome
- perikaryon
- dendrites
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Adcy3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cAMP biosynthetic process
- sperm motility
- acrosome reaction
- signal transduction
- sensory perception of smell
- olfactory learning
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- single fertilization
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- cilium
- Golgi apparatus
- cilium membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- calmodulin binding
- metal ion binding
- adenylate cyclase activity