Pih1d1 Gene Summary [Rat]
Predicted to enable several functions, including enzyme binding activity; histone binding activity; and phosphoprotein binding activity. Predicted to be involved in several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and protein-containing complex assembly. Predicted to be located in nucleolus. Predicted to be part of R2TP complex; RPAP3/R2TP/prefoldin-like complex; and pre-snoRNP complex. Predicted to be active in cytoplasm. Orthologous to human PIH1D1 (PIH1 domain containing 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pih1d1 |
| Official Name | PIH1 domain containing 1 [Source:RGD Symbol;Acc:1309809] |
| Ensembl ID | ENSRNOG00000020634 |
| Bio databases IDs | |
| Aliases | PIH1 domain containing 1 |
| Synonyms | 1110061L23Rik, 4933413A04Rik, DNAAF14, FLJ20643, MOT48, NOP17, PIH1, PIH1 domain containing 1, RGD1309809 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pih1d1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- ATPase binding
- protein kinase binding
- alpha-crystallin Hsps/p23-like
- protein binding activity, bridging
- phosphoprotein binding
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pih1d1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- snoRNA localization
- epithelial cell differentiation
- chromatin remodeling
- box C/D snoRNP assembly
- rRNA processing
- protein stabilization
- positive regulation of protein serine/threonine kinase activity
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- R2TP complex
- pre-snoRNP complex
- cytoplasm
- nucleolus
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- RNA polymerase I upstream control element sequence-specific DNA binding
- protein binding
- histone binding
- phosphoprotein binding
- ATPase binding