Mre11 Gene Summary [Rat]
Predicted to enable 3'-5'-DNA exonuclease activity; identical protein binding activity; and single-stranded DNA endodeoxyribonuclease activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Involved in heart development and host-mediated suppression of symbiont invasion. Located in chromatin; nuclear lumen; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mre11 |
| Official Name | MRE11 homolog, double strand break repair nuclease [Source:RGD Symbol;Acc:69263] |
| Ensembl ID | ENSRNOG00000009506 |
| Bio databases IDs | |
| Aliases | MRE11 homolog, double strand break repair nuclease |
| Synonyms | ATLD, HNGS1, MRE11A, MRE11A homolog A, double strand break repair nuclease, MRE11B, MRE11 homolog, double strand break repair nuclease, Rad32 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mre11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA repair protein (mre11)
- 3'-5' exonuclease
- nuclease
- central domain
- enzyme
- Mre11 DNA-binding presumed domain
- metallophosphatase superfamily, metallophosphatase domain
- protein binding
- identical protein binding
- 3'-5' exodeoxyribonuclease
- single-stranded DNA specific endodeoxyribonuclease
- DNA binding
- DNA helicase
- endonuclease
- double-stranded DNA binding
Pathways
Biological processes and signaling networks where the Mre11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- ATM Signaling
- DNA Double-Strand Break Repair by Homologous Recombination
- DNA Double-Strand Break Repair by Non-Homologous End Joining
- Hereditary Breast Cancer Signaling
- Molecular Mechanisms of Cancer
- Role of BRCA1 in DNA Damage Response
- Role of CHK Proteins in Cell Cycle Checkpoint Control
- Telomere Extension by Telomerase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- lymphomagenesis
- cancer
- gastrointestinal neoplasia
- epithelial neoplasia
- prostate cancer
- ataxia-telangiectasia-like disorder type 1
- ataxia-telangiectasia-like disorder
- bladder cancer
- hereditary cancer-predisposing syndrome
- breast cancer
role in cell
- phosphorylation in
- expression in
- activation in
- production in
- apoptosis
- survival
- proliferation
- length
- DNA damage response
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- nuclear fraction
- Cytoplasm
- perinuclear region
- cytoplasmic aggregates
- cytosol
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
- DNA replication foci
- PML nuclear bodies
- synaptonemal complexes
- telomeres
- chromatin
- replication fork
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mre11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- mitotic cell cycle G2/M transition DNA damage checkpoint
- DNA repair
- negative regulation of double-strand break repair via nonhomologous end joining
- reciprocal meiotic recombination
- regulation of mitotic recombination
- double-strand break repair via nonhomologous end joining
- meiotic DNA double-strand break formation
- double-strand break repair
- positive regulation of protein autophosphorylation
- DNA duplex unwinding
- positive regulation of kinase activity
- intra-S DNA damage checkpoint
- positive regulation of telomere maintenance
- sister chromatid cohesion
- DNA double-strand break processing
- DNA recombination
- double-strand break repair via homologous recombination
- telomere maintenance
- telomere maintenance via telomerase
- response to DNA damage stimulus
- synapsis
- negative regulation of apoptotic process
- telomeric 3' overhang formation
- reciprocal DNA recombination
Cellular Component
Where in the cell the gene product is active
- replication fork
- nucleus
- chromosome, telomeric region
- site of double-strand break
- PML body
- cytoplasm
- BRCA1-C complex
- cytosol
- Mre11 complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- 3'-5'-exodeoxyribonuclease activity
- double-stranded DNA binding
- endodeoxyribonuclease activity
- single-stranded DNA specific endodeoxyribonuclease activity
- DNA binding
- 3'-5' exonuclease activity
- DNA helicase activity
- protein binding
- cadherin binding
- nuclease activity
- manganese ion binding