Atrip Gene Summary [Rat]
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity. Predicted to be involved in DNA repair. Predicted to be located in nucleoplasm. Predicted to be part of ATR-ATRIP complex. Orthologous to human ATRIP (ATR interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atrip |
| Official Name | ATR interacting protein [Source:RGD Symbol;Acc:1626390] |
| Ensembl ID | ENSRNOG00000020670 |
| Bio databases IDs | |
| Aliases | ATR interacting protein |
| Synonyms | 6620401K05RIK, ATR interacting protein, LOC100911807 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Atrip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Prefoldin subunit
- Control of competence regulator ComK, YlbF/YmcA
- Ezrin/radixin/moesin, alpha-helical domain
- prefoldin
- coiled-coil domain
- protein binding
- Outer membrane protein (OmpH-like)
- Domain of unknown function (DUF4200)
- phosphorylation site
Pathways
Biological processes and signaling networks where the Atrip gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast carcinoma
- hereditary disorder
- systemic lupus erythematosus
- migraines
- Aicardi-Goutieres syndrome 1
- TREX1-related disorder
- chilblain lupus 1
- vasculopathy, retinal, with cerebral leukodystrophy
- autosomal dominant Aicardi-Goutieres syndrome type 1
- thrombotic microangiopathy
role in cell
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear foci
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Atrip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA damage checkpoint
- DNA repair
- regulation of double-strand break repair
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- ATR-ATRIP complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- K63-linked polyubiquitin binding