Nek8 Gene Summary [Rat]
Predicted to enable several functions, including ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to be involved in animal organ morphogenesis and regulation of hippo signaling. Predicted to act upstream of or within determination of left/right symmetry and heart development. Predicted to be located in ciliary base and ciliary inversin compartment. Predicted to be active in cilium. Used to study nephronophthisis 9. Human ortholog(s) of this gene implicated in nephronophthisis 9 and renal-hepatic-pancreatic dysplasia. Orthologous to human NEK8 (NIMA related kinase 8). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nek8 |
| Official Name | NIMA-related kinase 8 [Source:RGD Symbol;Acc:1306897] |
| Ensembl ID | ENSRNOG00000012866 |
| Bio databases IDs | |
| Aliases | NIMA-related kinase 8 |
| Synonyms | 4632401F23Rik, b2b1449Clo, JCK, NEK12A, NIMA (never in mitosis gene a)-related expressed kinase 8, NIMA-related kinase 8, NPHP9, PKD8, RHPD2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nek8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Regulator of chromosome condensation (RCC1) repeat
- Protein kinase (unclassified specificity)
- Protein Kinases, catalytic domain
- Protein tyrosine and serine/threonine kinase
- protein binding
- Protein kinase domain
- Tyrosine kinase, catalytic domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplasia
- bleeding
- organismal death
- nephronophthisis type 9
- atrioventricular septal defect
- renal-hepatic-pancreatic dysplasia type 2
- esophageal adenocarcinoma
- esophageal carcinoma formation
- congenital heart disease
role in cell
- expression in
- proliferation
- survival
- degradation in
- migration
- disassembly
- formation in
- invasion by
- G2/M phase
- collapse
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoskeleton
- Cytoplasm
- cilia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nek8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of hippo signaling cascade
- heart development
- determination of left/right symmetry
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- centrosome
- cytoplasm
- cilium
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity