NEWGENE_1306714 Gene Summary [Rat]
Involved in several processes, including positive regulation of neuroblast proliferation; positive regulation of neuron migration; and regulation of centrosome cycle. Predicted to be located in cytosol; microtubule cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in intellectual disability; polymicrogyria; primary autosomal recessive microcephaly; and primary autosomal recessive microcephaly 2 with or without cortical malformations. Orthologous to human WDR62 (WD repeat domain 62). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | NEWGENE_1306714 |
| Official Name | WD repeat domain 62-like 1 [Source:RGD Symbol;Acc:11427960] |
| Ensembl ID | ENSRNOG00000020807 |
| Bio databases IDs | |
| Aliases | WD repeat domain 62-like 1 |
| Synonyms | 2310038K02Rik, b2b1508Clo, C19orf14, DKFZP434J046, LOC100911863, MCPH2, NEWGENE 1306714, RGD1306714, WD repeat domain 62 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Newgene_1306714 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- WD40 repeats
- MKK7 binding domain
- alpha helix
- WD domain, G-beta repeat
- WD40
- protein binding
- Jnk-binding domain
- loop domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- autosomal recessive primary microcephaly type 2
- organismal death
- overall survival
- mental retardation
- hereditary disorder
- autosomal recessive primary microcephaly 2 with cortical malformations
- primary microcephaly
- autosomal recessive nonsyndromic mental retardation
- Skraban-Deardorff syndrome
regulated by
- arsenite
role in cell
- activation in
- expression in
- migration
- differentiation
- proliferation
- apoptosis
- number
- cell cycle progression
- temozolomide resistance
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- centrosome
- Golgi Apparatus
- cytosol
- spindle pole
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Newgene_1306714 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- centriole replication
- mitotic spindle organization
- positive regulation of neuroblast proliferation
- neurogenesis
- regulation of neuron differentiation
- cerebral cortex development
- regulation of centrosome cycle
- positive regulation of neuron migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- mitotic spindle
- centriole
- centriolar satellite
- spindle pole
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding