LOC100360087 Gene Summary [Rat]
This gene encodes the light subunit of the ferritin protein. Ferritin is the major intracellular iron storage protein in prokaryotes and eukaryotes. It is composed of 24 subunits of the heavy and light ferritin chains. Variation in ferritin subunit composition may affect the rates of iron uptake and release in different tissues. A major function of ferritin is the storage of iron in a soluble and nontoxic state. Defects in this light chain ferritin gene are associated with several neurodegenerative diseases and hyperferritinemia-cataract syndrome. This gene has multiple pseudogenes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LOC100360087 |
| Official Name | ferritin light chain 1-like [Source:RGD Symbol;Acc:2322860] |
| Ensembl ID | ENSRNOG00000020843 |
| Bio databases IDs | |
| Aliases | ferritin light chain 1-like |
| Synonyms | FERRITIN LIGHT CHAIN, ferritin light chain 1, ferritin light polypeptide 1, FL, FRIL, Fril1, FTL1, L-ferritin, LFTD, NBIA3, YB24D08 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Loc100360087 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ferritin-like domain
- iron ion binding
- protein binding
- identical protein binding
- Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Pathways
Biological processes and signaling networks where the Loc100360087 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Parkinson disease
- nonalcoholic fatty liver disease
- organismal death
- hepatocellular carcinoma
- liver cancer
- non-small cell lung carcinoma
- hereditary disorder
- pigmented villonodular synovitis
- Alzheimer disease
role in cell
- formation
- formation in
- expression in
- production in
- proliferation
- growth
- M2 polarization
- survival
- abnormal morphology
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- azurophil granule lumen
- Cytoplasm
- organelle lumens
- Nucleus
- cytosol
- autolysosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Loc100360087 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- iron ion transport
- intracellular sequestering of iron ion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- ferritin complex
- membrane
- cytosol
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ferric iron binding
- ferrous iron binding
- iron ion binding