Ftl1 Gene Summary [Mouse]
Predicted to enable ferric iron binding activity; ferrous iron binding activity; and identical protein binding activity. Predicted to be involved in intracellular iron ion homeostasis and iron ion transport. Predicted to be located in autolysosome. Predicted to be part of ferritin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; ciliary body; liver; and retina nuclear layer. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ftl1 |
| Official Name | ferritin light polypeptide 1 [Source:MGI Symbol;Acc:MGI:95589] |
| Ensembl ID | ENSMUSG00000050708 |
| Bio databases IDs | |
| Aliases | ferritin light polypeptide 1 |
| Synonyms | FERRITIN LIGHT CHAIN, ferritin light chain 1, ferritin light polypeptide 1, FL, FRIL, Fril1, FTL1, L-ferritin, LFTD, NBIA3, YB24D08 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ftl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Ferritin-like domain
- iron ion binding
- protein binding
- identical protein binding
- Ferritin-like superfamily of diiron-containing four-helix-bundle proteins
Pathways
Biological processes and signaling networks where the Ftl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Parkinson disease
- nonalcoholic fatty liver disease
- organismal death
- hepatocellular carcinoma
- liver cancer
- non-small cell lung carcinoma
- hereditary disorder
- pigmented villonodular synovitis
- Alzheimer disease
role in cell
- formation
- formation in
- expression in
- production in
- proliferation
- growth
- M2 polarization
- survival
- abnormal morphology
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- azurophil granule lumen
- Cytoplasm
- organelle lumens
- Nucleus
- cytosol
- autolysosomes
- phagosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ftl1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- iron ion transport
- intracellular sequestering of iron ion
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- ferritin complex
- membrane
- cytosol
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- ferric iron binding
- ferrous iron binding
- iron ion binding