Lin37 Gene Summary [Rat]
Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within G0 to G1 transition and gene expression. Predicted to be part of Myb complex. Orthologous to human LIN37 (lin-37 DREAM MuvB core complex component). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lin37 |
| Official Name | lin-37 DREAM MuvB core complex component [Source:RGD Symbol;Acc:1308901] |
| Ensembl ID | ENSRNOG00000020929 |
| Bio databases IDs | |
| Aliases | lin-37 DREAM MuvB core complex component |
| Synonyms | 1810054G18Rik, F25965, lin-37 DREAM MuvB core complex component, RGD1308901, ZK418.4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Lin37 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- LIN37
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Lin37 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcriptional repressor complex
- Myb complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding