Rbl2 Gene Summary [Rat]
Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of G1/S transition of mitotic cell cycle; and regulation of lipid kinase activity. Predicted to act upstream of or within negative regulation of gene expression. Located in chromatin. Orthologous to human RBL2 (RB transcriptional corepressor like 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbl2 |
| Official Name | RB transcriptional corepressor like 2 [Source:RGD Symbol;Acc:3541] |
| Ensembl ID | ENSRNOG00000012153 |
| Bio databases IDs | |
| Aliases | RB transcriptional corepressor like 2 |
| Synonyms | BRUWAG, P130, PRB2, Rb2, RB-LIKE protein 2, RBR-2, RB transcriptional corepressor like 2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rbl2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pocket domain
- SV40 large T-antigen binding domain
- Cyclin box fold superfamily
- Retinoblastoma-associated protein B domain
- chromatin binding
- domain present in cyclins, TFIIB and Retinoblastoma
- protein binding
- Retinoblastoma-associated protein A domain
- Domain of unknown function (DUF3452)
- loop domain
- cyclin-binding domain
- B subdomain from retinoblastoma
Pathways
Biological processes and signaling networks where the Rbl2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Aryl Hydrocarbon Receptor Signaling
- Bladder Cancer Signaling
- Chronic Myeloid Leukemia Signaling
- Cyclins and Cell Cycle Regulation
- DNA Methylation and Transcriptional Repression Signaling
- Glioma Signaling
- HER-2 Signaling in Breast Cancer
- Molecular Mechanisms of Cancer
- Non-Small Cell Lung Cancer Signaling
- Ovarian Cancer Signaling
- Pancreatic Adenocarcinoma Signaling
- Prostate Cancer Signaling
- Role of BRCA1 in DNA Damage Response
- Role of Tissue Factor in Cancer
- Serotonin Receptor Signaling
- Small Cell Lung Cancer Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- epithelial neoplasia
- cancer
- lung cancer
- Brunet-Wagner neurodevelopmental syndrome
- glioma formation
- organismal death
- Waldenström macroglobulinemia
- growth failure
role in cell
- expression in
- phosphorylation in
- quantity
- formation
- apoptosis
- proliferation
- accumulation
- growth
- activation in
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- chromosome
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rbl2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- regulation of lipid kinase activity
- cell differentiation
- negative regulation of G1/S transition of mitotic cell cycle
- chromatin organization
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- extracellular vesicular exosome
- cytosol
- chromosome
- nucleolus
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II regulatory region sequence-specific DNA binding