Rbl1

Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; negative regulation of cellular senescence; and regulation of lipid kinase activity. Predicted to act upstream of or within negative regulation of gene expression and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of transcription regulator complex. Predicted to be active in chromatin. Orthologous to human RBL1 (RB transcriptional corepressor like 1). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rbl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Rbl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the rat Rbl1 gene, providing context for its role in the cell.