Ms4a1 Gene Summary [Rat]
Enables epidermal growth factor receptor binding activity. Predicted to be involved in several processes, including B cell receptor signaling pathway; calcium ion transport; and positive regulation of calcium ion import across plasma membrane. Predicted to act upstream of or within response to bacterium. Predicted to be located in cell surface; nucleoplasm; and plasma membrane raft. Predicted to be active in external side of plasma membrane. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in common variable immunodeficiency 5. Orthologous to human MS4A1 (membrane spanning 4-domains A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ms4a1 |
| Official Name | membrane spanning 4-domains A1 [Source:RGD Symbol;Acc:1311999] |
| Ensembl ID | ENSRNOG00000020945 |
| Bio databases IDs | |
| Aliases | membrane spanning 4-domains A1 |
| Synonyms | B1, Bp35, CD20, CVID5, Fcer1b, FMC7, LEU-16, Ly-44, membrane spanning 4-domains A1, membrane-spanning 4-domains, subfamily A, member 1, MS4A2, S7 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ms4a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- epidermal growth factor receptor binding
- protein binding
- identical protein binding
- immunoglobulin binding
- CD20-like family
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- leukemia
- neoplasia
- myelodysplastic syndrome
- diabetic nephropathy
- follicular B-cell or T-cell lymphoma
- diffuse large B-cell lymphoma
- Waldenström macroglobulinemia
- mantle cell lymphoma
- grade 1 follicular lymphoma
role in cell
- apoptosis
- expression in
- activation in
- proliferation
- production in
- differentiation
- activation
- cell death
- growth
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- cellular membrane
- membrane compartment
- plasma membrane extracellular face
- nucleoplasm
- membrane rafts
- microvilli
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ms4a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- store-operated calcium entry
- response to bacterium
- B cell differentiation
- protein tetramerization
- humoral immune response
- B cell proliferation
- cell surface receptor signaling pathway
- B cell activation
- B cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- external side of plasma membrane
- plasma membrane
- cell surface
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- epidermal growth factor receptor binding
- MHC class II protein complex binding
- immunoglobulin binding