Cgn Gene Summary [Rat]
Predicted to enable microtubule binding activity. Predicted to be involved in microtubule cytoskeleton organization. Predicted to act upstream of or within bicellular tight junction assembly and epithelial cell morphogenesis. Predicted to be located in apical junction complex; brush border; and plasma membrane. Predicted to be part of myosin complex. Predicted to be active in bicellular tight junction. Orthologous to human CGN (cingulin). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cgn |
| Official Name | cingulin [Source:RGD Symbol;Acc:1311992] |
| Ensembl ID | ENSRNOG00000020952 |
| Bio databases IDs | |
| Aliases | cingulin |
| Synonyms | 6330408J11Rik, AI987749, cingulin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cgn often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Crescentin protein
- Mitotic checkpoint protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Synaptonemal complex protein 1 (SCP-1)
- Myosin tail
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- globular head domain
- chromosome segregation protein SMC, common bacterial type
- microtubule binding
- RecF/RecN/SMC N terminal domain
- actin binding
- Coiled-coil domain-containing protein 158
- tail domain
- rod domain
Pathways
Biological processes and signaling networks where the Cgn gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hearing loss
- prostate cancer
- renal clear cell adenocarcinoma
- renal clear cell cancer
- nonsyndromic autosomal dominant hearing impairment
role in cell
- activation in
- permeability
- binding
- degeneration
- organization
- assembly
- morphology
- morphogenesis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- Cytoplasm
- intercellular junctions
- cell-cell contacts
- cuticular plate
- tight junctions
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cgn gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- myosin complex
- tight junction
- cell junction
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- actin binding
- cadherin binding
- microtubule binding