Tjp3 Gene Summary [Rat]
Predicted to enable cell adhesion molecule binding activity. Predicted to be involved in several processes, including establishment of endothelial intestinal barrier; positive regulation of blood-brain barrier permeability; and protein localization to cell-cell junction. Predicted to act upstream of or within regulation of G1/S transition of mitotic cell cycle. Located in cell-cell junction. Orthologous to human TJP3 (tight junction protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tjp3 |
| Official Name | tight junction protein 3 [Source:RGD Symbol;Acc:1309247] |
| Ensembl ID | ENSRNOG00000020501 |
| Bio databases IDs | |
| Aliases | tight junction protein 3 |
| Synonyms | tight junction protein 3, ZO-3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tjp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- guanylate kinase
- Domain present in PSD-95, Dlg, and ZO-1/2
- NK
- canonical PDZ domain
- protein binding
- PDZ domain
- PDZ binding motif
- cpPDZ_Deg_HtrA-like
- cpPDZ_RseP_YlbL-like
- Src Homology 3 domain superfamily
Pathways
Biological processes and signaling networks where the Tjp3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colon cancer
- melanoma
- melanoma cancer
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- androgenic alopecia
- cleft lip
role in cell
- growth
- development
- stabilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell junction
- cell surface
- apical compartment
- Nucleus
- Plasma Membrane
- intercellular junctions
- cell-cell contacts
- cytosol
- apical membrane
- nucleoplasm
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tjp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell junction organization
- maintenance of blood-brain barrier
Cellular Component
Where in the cell the gene product is active
- nucleus
- tight junction
- cell junction
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cell adhesion molecule binding