Spaca4 Gene Summary [Rat]

Predicted to be involved in binding activity of sperm to zona pellucida. Predicted to be located in inner acrosomal membrane and outer acrosomal membrane. Predicted to be active in membrane. Orthologous to human SPACA4 (sperm acrosome associated 4). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Spaca4
Official Name
sperm acrosome associated 4 [Source:RGD Symbol;Acc:1587464]
Ensembl ID
ENSRNOG00000021037
Bio databases IDs NCBI: 691120 Ensembl: ENSRNOG00000021037
Aliases sperm acrosome associated 4
Synonyms 1700008E09RIK, LOC687988, SAMP14, sperm acrosome associated 4
Species
Rat, Rattus norvegicus
OrthologiesHumanMouse

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Spaca4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • TFP

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • asthenozoospermia
regulated by
  • PGAP6
role in cell
  • binding
  • fertilization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • cytoplasmic vesicle membrane
  • Extracellular Space
  • Plasma Membrane
  • acrosome

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the rat Spaca4 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • sperm-egg recognition
  • cell adhesion

Cellular Component

Where in the cell the gene product is active
  • acrosomal vesicle
  • membrane
  • extracellular region
  • plasma membrane

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.