Mvk Gene Summary [Rat]
Enables several functions, including ATP binding activity; magnesium ion binding activity; and mevalonate kinase activity. Involved in isopentenyl diphosphate biosynthetic process, mevalonate pathway and negative regulation of translation. Located in peroxisome. Human ortholog(s) of this gene implicated in hyperimmunoglobulinemia D periodic fever syndrome; lipid metabolism disorder; mevalonic aciduria; and porokeratosis. Orthologous to human MVK (mevalonate kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mvk |
| Official Name | mevalonate kinase [Source:RGD Symbol;Acc:621295] |
| Ensembl ID | ENSRNOG00000049604 |
| Bio databases IDs | |
| Aliases | mevalonate kinase |
| Synonyms | 2310010A05Rik, LRBP, MEVALONATE KINASE, MK, MK1, MVLK, POROK3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Mvk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Galactokinase galactose-binding signature
- mRNA binding
- ATP binding
- GHMP kinases N terminal domain
- protein binding
- magnesium ion binding
- identical protein binding
- mevalonate kinase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
- colorectal cancer
- experimental autoimmune encephalomyelitis
- hereditary disorder
- mevalonic aciduria
- sporadic disseminated superficial actinic porokeratosis
- hyper-IgD syndrome
- MVK-related disorder
- familial disseminated superficial actinic porokeratosis
- retinal dystrophy
role in cell
- apoptosis
- growth
- survival
- morphology
- differentiation
- binding in
- degradation in
- translation in
- ubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- intracellular membrane-bounded organelle
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Mvk gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of inflammatory response
- isopentenyl diphosphate biosynthetic process, mevalonate pathway
- cholesterol biosynthetic process
- isoprenoid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- peroxisome
- intracellular membrane-bounded organelle
- cytosol
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- identical protein binding
- protein binding
- mevalonate kinase activity