Tirap Gene Summary [Rat]
Predicted to enable several functions, including Toll-like receptor binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein kinase C binding activity. Predicted to be involved in several processes, including TIRAP-dependent toll-like receptor 4 signaling pathway; positive regulation of signal transduction; and regulation of gene expression. Predicted to act upstream of or within several processes, including myeloid cell differentiation; positive regulation of macrophage cytokine production; and response to bacterium. Predicted to be located in endocytic vesicle and ruffle membrane. Predicted to be active in cell surface; cytoplasm; and plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tirap |
| Official Name | TIR domain containing adaptor protein [Source:RGD Symbol;Acc:1595496] |
| Ensembl ID | ENSRNOG00000021420 |
| Bio databases IDs | |
| Aliases | TIR domain containing adaptor protein |
| Synonyms | BACTS1, C130027E04RIK, LOC681662, MAL, MyD88-2, TIR domain containing adaptor protein, Tlr4ap, toll-interleukin 1 receptor (TIR) domain-containing adaptor protein, Wyatt |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tirap often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TRAF6 binding domain
- SH4 domain
- phosphatidylinositol 4,5-biphosphate binding domain
- BB loop
- phosphatidylinositol-4,5-bisphosphate binding
- protein kinase C binding
- protein binding activity, bridging
- protein binding
- receptor binding
- TIR domain
- identical protein binding
- Toll IL-1 receptor domain helix B
Pathways
Biological processes and signaling networks where the Tirap gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- bronchoconstriction
- malaria
- endotoxin shock response
- tuberculosis
- resistance to malaria
- bacteremia
- pathogenesis
- invasive pneumococcal disease
- infection
role in cell
- proliferation
- expression in
- accumulation
- apoptosis
- production in
- quantity
- differentiation
- formation in
- phosphorylation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- Plasma Membrane
- vesicles
- cytosol
- cytoplasmic face of plasma membrane
- membrane ruffles
- endocytotic vesicle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tirap gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of chemokine (C-X-C motif) ligand 1 production
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of NF-kappaB transcription factor activity
- inflammatory response
- MyD88-dependent toll-like receptor signaling pathway
- regulation of interferon-beta production
- positive regulation of tumor necrosis factor production
- positive regulation of protein complex assembly
- defense response to Gram-positive bacterium
- positive regulation of toll-like receptor 3 signaling pathway
- 3'-UTR-mediated mRNA stabilization
- positive regulation of toll-like receptor 4 signaling pathway
- positive regulation of neutrophil chemotaxis
- toll-like receptor 4 signaling pathway
- cell surface receptor signaling pathway
- positive regulation of interleukin-15 production
- positive regulation of interleukin-12 production
- positive regulation of interleukin-8 production
- cellular response to lipoteichoic acid
- innate immune response
- positive regulation of JNK cascade
- regulation of innate immune response
- positive regulation of ERK1 and ERK2 cascade
- cellular response to bacterial lipopeptide
- myeloid cell differentiation
- positive regulation of toll-like receptor 2 signaling pathway
- positive regulation of B cell proliferation
- positive regulation of chemokine (C-X-C motif) ligand 2 production
- response to lipopolysaccharide
- positive regulation of interleukin-6 production
- TIRAP-dependent toll-like receptor 4 signaling pathway
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle
- cytoplasm
- ruffle membrane
- cytosol
- extrinsic to internal side of plasma membrane
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein kinase C binding
- phosphatidylinositol-4,5-bisphosphate binding
- Toll-like receptor 4 binding
- identical protein binding
- protein binding
- Toll-like receptor 2 binding
- signaling adaptor activity
- protein binding, bridging
- binding, bridging