Details
| Type | Protein Coding |
| Official Symbol | Cxcl1 |
| Official Name | C-X-C motif chemokine ligand 1 [Source:RGD Symbol;Acc:619869] |
| Ensembl ID | ENSRNOG00000002802 |
| Bio databases IDs | |
| Aliases | C-X-C motif chemokine ligand 1 |
| Synonyms | CINC-1, C-X-C motif chemokine ligand 1, Fsp, Gro, Gro1, Gro alpha, Gro α, KC, KC-GRO, Keratinocyte-derived chemokine, Keratinocyte-derived cytokine, Mgsa, N51, Scyb1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cxcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- chemokine
- Small cytokines (intecrine/chemokine), interleukin-8 like
- cytokine
Pathways
Biological processes and signaling networks where the Cxcl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Granulocyte Adhesion and Diapedesis
- IL-17 Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- IL-8 Signaling
- Lymphotoxin β Receptor Signaling
- Role of IL-17A in Arthritis
- Role of IL-17A in Psoriasis
- Role of IL-17F in Allergic Inflammatory Airway Diseases
- Role of Tissue Factor in Cancer
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- metastasis
- pulmonary fibrosis
- experimentally-induced arthritis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
- hypernociception
- atherosclerosis
- Marfan syndrome
phenotypes
- Acute Lung Injury
- Acute Necrotizing Pancreatitis
- Alcoholic Liver Diseases
- Animal Hepatitis
- Brain Injuries
- Bronchopulmonary Dysplasia
- Burns
- Endotoxemia
- Enteritis
- Experimental Arthritis
- Femoral Fractures
- Hemorrhage
- human influenza
- Inflammation
- Legionnaires' Disease
- Liver Reperfusion Injury
- Myocardial Reperfusion Injury
- Nasal Polyps
- Pneumococcal Meningitis
- Pneumococcal Pneumonia
- Reperfusion Injury
- Shock Hemorrhagic
- Spinal Cord Injuries
- Stroke
- Subarachnoid Hemorrhage
- Ventricular Dysfunction Right
- acute kidney failure
- aspiration pneumonia
- asthma
- bacterial pneumonia
- chronic obstructive pulmonary disease
- Common Cold
- Cystic Fibrosis
- dilated cardiomyopathy
- esophageal cancer
- Hyperhomocysteinemia
- lung disease
- Plague
- Pleurisy
- Pneumonia
- Prostatitis
- Pulmonary Emphysema
- respiratory syncytial virus infectious disease
- Severe Acute Respiratory Syndrome
- Status Epilepticus
- viral pneumonia
- Hemorrhagic Shock
role in cell
- activation
- production in
- cellular infiltration by
- proliferation
- number
- expression in
- recruitment
- frequency
- quantity
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- intracellular space
- perinuclear region
- exosomes
- plasma