Rnf216 Gene Summary [Rat]
Predicted to enable ubiquitin protein ligase activity. Involved in protein catabolic process, modulating synaptic transmission and regulation of postsynaptic neurotransmitter receptor internalization. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic endocytic zone. Human ortholog(s) of this gene implicated in Gordon Holmes syndrome. Orthologous to human RNF216 (ring finger protein 216). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf216 |
| Official Name | ring finger protein 216 [Source:RGD Symbol;Acc:1565135] |
| Ensembl ID | ENSRNOG00000001101 |
| Bio databases IDs | |
| Aliases | ring finger protein 216 |
| Synonyms | 2810055G22Rik, AI647468, AU019462, C86502, CAHH, F830018F18Rik, RGD1565135, ring finger protein 216, TRIAD3, U7I1, UBCE7IP1, UIP83, ZIN |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Rnf216 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ring like zinc finger domain
- TRAF binding domain
- ubiquitin protein ligase activity
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- BRcat_Rcat_RBR
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- organismal death
- cerebellar ataxia and hypogonadotropic hypogonadism
- silicosis
- mucopolysaccharidosis type IVB
- brain edema
- placenta accreta spectrum
- infection by HIV-1
- infection by vesicular stomatitis virus
regulated by
- BAY 41-2272
- epigallocatechin-gallate
- Sendai virus
- NS 2028
- vesicular stomatitis virus
- oxyhemoglobin
role in cell
- apoptosis
- expression in
- production in
- migration
- phosphorylation in
- activation in
- survival
- degradation in
- downregulation in
- signaling in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- presynaptic regions
- Nucleus
- cytosol
- nucleoplasm
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Rnf216 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of type I interferon production
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of interferon-beta production
- protein K48-linked ubiquitination
- apoptotic process
- regulation of defense response to virus by host
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- clathrin-coated vesicle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein binding