Uprt Gene Summary [Rat]
This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]
Details
| Type | Protein Coding |
| Official Symbol | Uprt |
| Official Name | uracil phosphoribosyltransferase homolog [Source:RGD Symbol;Acc:1564806] |
| Ensembl ID | ENSRNOG00000021552 |
| Bio databases IDs | |
| Aliases | uracil phosphoribosyltransferase homolog |
| Synonyms | D830012I24Rik, FUR1, Gm774, LOC107985663, RGD1564806, UPP, uracil phosphoribosyltransferase, uracil phosphoribosyltransferase homolog |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Uprt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- uracil phosphoribosyltransferase
- Phosphoribosyl transferase (PRT)-type I domain
- enzyme
- protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Uprt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to insulin stimulus
- UMP biosynthetic process
- female pregnancy
- lactation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- intracellular membrane-bounded organelle
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- ribosylnicotinamide kinase activity