Pyroxd1 Gene Summary [Rat]
Predicted to enable oxidoreductase activity. Predicted to be involved in cellular response to oxidative stress. Predicted to be located in nucleus and sarcomere. Human ortholog(s) of this gene implicated in myofibrillar myopathy 8. Orthologous to human PYROXD1 (pyridine nucleotide-disulphide oxidoreductase domain 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pyroxd1 |
| Official Name | pyridine nucleotide-disulphide oxidoreductase domain 1 [Source:RGD Symbol;Acc:1303253] |
| Ensembl ID | ENSRNOG00000012472 |
| Bio databases IDs | |
| Aliases | pyridine nucleotide-disulphide oxidoreductase domain 1 |
| Synonyms | FLJ22028, MFM8, pyridine nucleotide-disulphide oxidoreductase domain 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pyroxd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pyridine nucleotide-disulphide oxidoreductase
- NADPH oxidase
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- sarcomere
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pyroxd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- sarcomere
Molecular Function
What the gene product does at the molecular level
- protein binding
- oxidoreductase activity
- flavin adenine dinucleotide binding